Targeting CREB for Cancer Therapy: Friend or Foe
Abstract
The cyclic-AMP response element-binding protein (CREB) is a nuclear transcription factor activated by phosphorylation at Ser133 by multiple serine/threonine (Ser/Thr) kinases. Upon phosphorylation, CREB binds the transcriptional co-activator, CBP (CREB-binding protein), to initiate CREB-dependent gene transcription. CREB is a critical regulator of cell differentiation, proliferation and survival in the nervous system. Recent studies have shown...
Paper Details
Title
Targeting CREB for Cancer Therapy: Friend or Foe
Published Date
Jun 1, 2010
Journal
Volume
10
Issue
4
Pages
384 - 391
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