Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1

Fibrillar amyloid plaques are largely composed of amyloid‐beta (Aβ) peptides that are metabolized into products, including Aβ1‐16, by proteases including matrix metalloproteinase 9 ( MMP ‐9). The balance between production and degradation of Aβ proteins is critical to amyloid accumulation and resulting disease. Regulation of MMP ‐9 and its endogenous inhibitor tissue inhibitor of metalloproteinase ( TIMP )‐1 by nitric oxide ( NO ) has been...