Early increase in urinary leukotriene E₄ (LTE₄) is dependent on allergen dose inhaled during bronchial challenge in asthmatic subjects

Urinary leukotriene E4 (LTE4) excretion is a good marker of the rate of total body production of sulfidopeptide leukotrienes released during allergen challenge.Twenty-three subjects with allergic asthma were challenged with inhaled allergen, and the urinary excretion of LTE4 was determined by immunoenzymatic assay (associated with HPLC separation) at various intervals after challenge.Allergen challenge caused an early airway response (EAR) with...