Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules
Abstract
For decades, the work of cell and developmental biologists has demonstrated the striking ability of the mesenchyme and the stroma to instruct epithelial form and function in the mammary gland, but the role of extracellular matrix (ECM) molecules in mammary pattern specification has not been elucidated. Here, we show that stromal collagen I (Col-I) fibers in the mammary fat pad are axially oriented prior to branching morphogenesis. Upon puberty,...
Paper Details
Title
Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules
Published Date
Apr 22, 2013
Journal
Volume
23
Issue
8
Pages
703 - 709
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