Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Abstract
The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key RIP3 (receptor interacting protein 3) downstream component of tumour necrosis factor (TNF)-induced necroptosis. MLKL is phosphorylated by RIP3 and is recruited to the necrosome through its interaction with RIP3. However, it is still unknown how MLKL mediates TNF-induced necroptosis. Here, we report that MLKL forms a homotrimer through its amino-terminal...
Paper Details
Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Published Date
Dec 8, 2013
Journal
Volume
16
Issue
1
Pages
55 - 65
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