Chagas disease: 100 years after its discovery. A systemic review

Although Chagas disease was only discovered in 1909, it began millions of years ago as an enzootic disease among wild animals. Its transmission to man began accidentally as an anthropozoonosis when mankind invaded wild ecotopes. Endemic Chagas disease became established as a zoonosis over the last 200–300 years through deforestation for agriculture and livestock rearing and adaptation of triatomines to dwellings and to humans and domestic...