Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
Abstract
Cancers exhibit extensive mutational heterogeneity, and the resulting long-tail phenomenon complicates the discovery of genes and pathways that are significantly mutated in cancer. We perform a pan-cancer analysis of mutated networks in 3,281 samples from 12 cancer types from The Cancer Genome Atlas (TCGA) using HotNet2, a new algorithm to find mutated subnetworks that overcomes the limitations of existing single-gene, pathway and network...
Paper Details
Title
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
Published Date
Dec 15, 2014
Journal
Volume
47
Issue
2
Pages
106 - 114
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