Adipose Tissue Extracellular Matrix and Vascular Abnormalities in Obesity and Insulin Resistance

Insulin resistance is associated with inflammation, fibrosis, and hypoxia in adipose tissue. This study was intended to better characterize the extracellular matrix (ECM) and vascularity of insulin-resistant adipose tissue. Adipose expression of collagens, elastin, and angiogenic factors was assessed using real-time RT-PCR and immunohistochemistry (IHC) in abdominal sc adipose tissue. Adipocyte-macrophage coculture experiments examined the...