HMGB 1 mediates hyperglycaemia‐induced cardiomyocyte apoptosis via ERK /Ets‐1 signalling pathway
Volume: 18, Issue: 11, Pages: 2311 - 2320
Published: Sep 11, 2014
Abstract
Apoptosis is a key event involved in diabetic cardiomyopathy. The expression of high mobility group box 1 protein (HMGB1) is up-regulated in diabetic mice. However, the molecular mechanism of high glucose (HG)-induced cardiomyocyte apoptosis remains obscure. We aimed to determine the role of HMGB1 in HG-induced apoptosis of cardiomyocytes. Treating neonatal primary cardiomyocytes with HG increased cell apoptosis, which was accompanied by...
Paper Details
Title
Published Date
Sep 11, 2014
Volume
18
Issue
11
Pages
2311 - 2320
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