Effect of prostaglandins F2 alpha and E2 on airway conductance in healthy subjects and asthmatic patients.

Effects of aerosol inhalation of prostaglandins F2alpha and E2 on specific airway conductance were studied in 12 healthy subjects and 17 patients with bronchial asthma. Approximately 50 per cent reduction of specific airway conductance was obtained with 250 to 1000 mug of prostaglandin F2alpha in healthy subjects and 4 to 512 ng of prostaglandin F2alpha in asthmatics. In healthy subjects, repeated administration of prostaglandin F2alpha within 1...