Effects of tyrosine kinase inhibitors on rat isolated heart function and protein biomarkers indicative of toxicity
Volume: 68, Issue: 1, Pages: 150 - 159
Published: Jul 1, 2013
Abstract
Cardiac toxicity, manifested as diminished contractility, ischemic heart disease, and heart failure is a major issue in drug safety. Concerns revolve around targeted drugs (TKIs) where contractility effects were not anticipated. The ability to predict cardiac toxicity early would help to de-risk drugs in development and prepare physicians to manage risk in the clinic. Issues with current preclinical studies include insufficient testing with...
Paper Details
Title
Effects of tyrosine kinase inhibitors on rat isolated heart function and protein biomarkers indicative of toxicity
Published Date
Jul 1, 2013
Volume
68
Issue
1
Pages
150 - 159
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