Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema.

Published on Dec 31, 2013in American Journal of Respiratory Cell and Molecular Biology5.373
· DOI :10.1165/RCMB.2012-0418OC
Genyo Ikeda7
Estimated H-index: 7
(Okayama University),
Nobuaki Miyahara33
Estimated H-index: 33
(RMIT: RMIT University)
+ 8 AuthorsArihiko Kanehiro25
Estimated H-index: 25
The incidence of overlapping bronchial asthma and chronic obstructive pulmonary disease has increased in recent years. Cysteinyl leukotrienes (CysLTs) play an important role in asthma, and the type 1 CysLT receptor (CysLT1R) is expressed by many inflammatory cells. We evaluated the effect of montelukast, a CysLT1R antagonist, on mouse models of asthma, porcine pancreatic elastase (PPE)-induced emphysema, and asthma combined with emphysema. Mice were sensitized with ovalbumin (OVA) on Days 0 and 14 and subsequently challenged with OVA on Days 28, 29, and 30. Pulmonary emphysema was induced by intratracheal instillation of PPE on Day 25. Mice were treated subcutaneously with montelukast or vehicle from Day 25 to Day 31. Airway hyperresponsiveness (AHR), static compliance; the number of inflammatory cells, the levels of cytokines, chemokines, LTs, and perforin in the bronchoalveolar lavage fluid, and the quantitative morphometry of lung sections were analyzed on Day 32. Treatment with montelukast significant...
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