Regulation of Estrogen Receptor α-mediated Transcription by a Direct Interaction with Protein Phosphatase 2A
Abstract
Estrogen receptor alpha (ERalpha) mediates the effects of estrogen by altering gene expression following hormone binding. It has recently been shown that kinase-mediated phosphorylation of ERalpha also transcriptionally activates the receptor in the absence of estrogen. We now report that ERalpha-dependent gene expression also is regulated by protein phosphatase 2A (PP2A). ERalpha co-immunoprecipitates with enzymatically active PP2A. ERalpha...
Paper Details
Title
Regulation of Estrogen Receptor α-mediated Transcription by a Direct Interaction with Protein Phosphatase 2A
Published Date
Feb 14, 2003
Volume
278
Issue
7
Pages
4639 - 4645
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