Factors Affecting Precipitation of Vancomycin and Ceftazidime on Intravitreal Injection

Purpose: The aim of this study was to investigate the factors that affect the precipitation of vancomycin and ceftazidime which are currently used in intravitreal injections for infectious endophthalmitis. Methods: The minimum concentration required for precipitation of the 2 antibiotics was estimated by 2-fold dilution. In addition, the amount of the precipitate that formed was measured at 4, 3, 2, and 1 mL volumes, temperatures (37°C or 4°C),...