New Approaches to Prediction of Immune Responses to Therapeutic Proteins during Preclinical Development
Abstract
Clinical studies show that immunogenicity observed against therapeutic proteins can limit efficacy and reduce the safety of the treatment. It is therefore beneficial to be able to predict the immunogenicity of therapeutic proteins before they enter the clinic. Studies using deimmunized proteins have highlighted the importance of T-cell epitopes in the generation of undesirable immunogenicity. In silico, in vitro, ex vivo and in vivo methods have...
Paper Details
Title
New Approaches to Prediction of Immune Responses to Therapeutic Proteins during Preclinical Development
Published Date
Jan 1, 2008
Journal
Volume
9
Issue
6
Pages
385 - 396
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