CPAF: a Chlamydial protease in search of an authentic substrate
Abstract
Bacteria in the genus Chlamydia are major human pathogens that cause an intracellular infection. A chlamydial protease, CPAF, has been proposed as an important virulence factor that cleaves or degrades at least 16 host proteins, thereby altering multiple cellular processes. We examined 11 published CPAF substrates and found that there was no detectable proteolysis when CPAF activity was inhibited during cell processing. We show that the reported...
Paper Details
Title
CPAF: a Chlamydial protease in search of an authentic substrate
Published Date
Aug 2, 2012
Journal
Volume
8
Issue
8
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