Genetic manipulation of B cells for the isolation of rare therapeutic antibodies from the human repertoire

Volume: 65, Issue: 1, Pages: 38 - 43
Published: Jan 1, 2014
Abstract
Antibody based therapies are increasingly applied to prevent and treat human disease. While the majority of antibodies currently on the market are chimeric or humanized antibodies from rodents, the focus has now shifted to the isolation and development of fully human antibodies. By retroviral transduction of B cell lymphoma-6 (BCL-6), which prevents terminal differentiation of B cells and, the anti-apoptotic gene B-cell lymphoma-extra large...
Paper Details
Title
Genetic manipulation of B cells for the isolation of rare therapeutic antibodies from the human repertoire
Published Date
Jan 1, 2014
Journal
Volume
65
Issue
1
Pages
38 - 43
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.