Structure elucidation and control of cyclic peptide-derived nanotube assemblies in solution

We describe the solution assembly of polymer–cyclic peptide conjugates into nanotubes, by direct in situ measurements. The conjugates were assembled by exploiting the β-sheet assembly of the alt(D,L) cyclic octapeptide core. The conjugated polymer permits solubilization of the peptide and the resulting nanotubes, thus allowing for the first time the direct study of the assembly mechanism of this system. The resulting materials present unique...