Evaluation of neutralized Chemical Agent Identification Sets (CAIS) for skin injury with an overview of the vesicant potential of agent degradation products

Vesication and skin irritation studies were conducted in hairless guinea-pigs to determine the vesicant and skin irritation potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). The CAIS are training items that contain chemical warfare-related material—sulfur mustard (HD), nitrogen mustard (HN) or lewisite (L)—and were declared obsolete in 1971. Animals were dosed topically with ‘test article’—neat HD, 10%...