P146 TLR2-ligands induce NF-κB activation exclusively from endosomal compartments

Volume: 59, Issue: 3, Pages: 567
Published: Sep 1, 2012
Abstract
Introduction null Antiphospholipid antibody syndrome (APS) is an auto-immune disease associated with arterial or venous thrombosis and/or recurrent fetal loss and is caused by pathogenic antiphospholipid antibodies (aPLA). We recently demonstrated TLR2 as a crucial factor in recognizing aPLA by monocytes. While TLR4 is known to transmit signals from both the plasma membrane and endosomal compartments, less is known about the function of...
Paper Details
Title
P146 TLR2-ligands induce NF-κB activation exclusively from endosomal compartments
Published Date
Sep 1, 2012
Journal
Volume
59
Issue
3
Pages
567
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