Simultaneous Bone Marrow and Composite Tissue Transplantation in Rats Treated With Nonmyeloablative Conditioning Promotes Tolerance

Background Approaches to safely induce tolerance in vascularized composite allotransplantation (VCA) with chimerism through bone marrow transplantation (BMT) are currently being pursued. However, VCA was historically performed sequentially after donor chimerism was established. Delayed VCA is not clinically applicable due to the time constraints associated with procurement from deceased donors. A more clinically relevant approach to perform both...