E2F1 in gliomas: A paradigm of oncogene addiction
Abstract
Cancer arises as a result of a stepwise accumulation of genetic changes. One of these changes, deregulation of the Rb/E2F1 pathway resulting from alterations in members of the pathway, is a hallmark of all human cancers. These mutations promote tumor development by deregulating the E2F family of transcription factors, which results in uncontrolled cell cycle progression. The E2F1 protein functions as a transcription factor that enhances cell...
Paper Details
Title
E2F1 in gliomas: A paradigm of oncogene addiction
Published Date
May 1, 2008
Journal
Volume
263
Issue
2
Pages
157 - 163
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