Metabolic activation of sulfur mustard leads to oxygen free radical formation
Abstract
We recently published electron paramagnetic resonance (EPR) spin trapping results that demonstrated the enzymatic reduction of sulfur mustard sulfonium ions to carbon-based free radicals using an in vitro system containing sulfur mustard, cytochrome P450 reductase, NADPH, and the spin trap α-(4-pyridyl-1-oxide)-N-tert-butylnitrone (4-POBN) in buffer (A.A. Brimfield et al., 2009, Toxicol. Appl. Pharmacol. 234:128–134). Carbon-based radicals have...
Paper Details
Title
Metabolic activation of sulfur mustard leads to oxygen free radical formation
Published Date
Feb 1, 2012
Volume
52
Issue
4
Pages
811 - 817
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