ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Science56.90
Volume: 308, Issue: 5721, Pages: 551 - 554
Published: Apr 22, 2005
Abstract
The ataxia-telangiectasia mutated (ATM) kinase signals the presence of DNA double-strand breaks in mammalian cells by phosphorylating proteins that initiate cell-cycle arrest, apoptosis, and DNA repair. We show that the Mre11-Rad50-Nbs1 (MRN) complex acts as a double-strand break sensor for ATM and recruits ATM to broken DNA molecules. Inactive ATM dimers were activated in vitro with DNA in the presence of MRN, leading to phosphorylation of the...
Paper Details
Title
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
Published Date
Apr 22, 2005
Journal
Volume
308
Issue
5721
Pages
551 - 554
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