Injectable hyaluronic acid-tyramine hydrogels incorporating interferon-α2a for liver cancer therapy
Abstract
We report an injectable hydrogel system that incorporates interferon-α2a (IFN-α2a) for liver cancer therapy. IFN-α2a was incorporated in hydrogels composed of hyaluronic acid-tyramine (HA-Tyr) conjugates through the oxidative coupling of Tyr moieties with hydrogen peroxide (H2O2) and horseradish peroxidase (HRP). IFN-α2a-incorporated HA-Tyr hydrogels of varying stiffness were formed by changing the H2O2 concentration. The incorporation of...
Paper Details
Title
Injectable hyaluronic acid-tyramine hydrogels incorporating interferon-α2a for liver cancer therapy
Published Date
Mar 1, 2013
Volume
166
Issue
3
Pages
203 - 210
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