Adeno-associated virus-mediated human IL-10 gene transfer suppresses the development of experimental autoimmune orchitis

Volume: 12, Issue: 14, Pages: 1126 - 1132
Published: May 26, 2005
Abstract
Testicular germ cell-induced autoimmune orchitis is characterized by inflammatory cell infiltration followed by disturbance of spermatogenesis. Experimental autoimmune orchitis (EAO) is an animal model for human immunological male infertility; delayed-type hypersensitivity (DTH) response plays a key role in its induction. Interleukin-10 (IL-10) is a regulatory cytokine that is critical in preventing organ-specific autoimmune inflammation. To...
Paper Details
Title
Adeno-associated virus-mediated human IL-10 gene transfer suppresses the development of experimental autoimmune orchitis
Published Date
May 26, 2005
Volume
12
Issue
14
Pages
1126 - 1132
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