(+)-Cholesten-3-one induces differentiation of neural stem cells into dopaminergic neurons through BMP signaling
Abstract
To identify small molecules that induce dopaminergic neurons from neural stem cells (NSCs) is promising for therapy of Parkinson's disease. Here we report the results of analyzing structurally related steroids in traditional Chinese medicine to identify agents that enhance dopaminergic differentiation of NSCs. Using P19 cells transfected by tyrosine hydroxylase (TH) promoter reporter construct, (+)-Cholesten-3-one with carbonyl, but not...
Paper Details
Title
(+)-Cholesten-3-one induces differentiation of neural stem cells into dopaminergic neurons through BMP signaling
Published Date
Nov 1, 2010
Journal
Volume
68
Issue
3
Pages
176 - 184
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