Development of RET Kinase Inhibitors for Targeted Cancer Therapy
Abstract
RET (Rearranged during Transfection) is a transmembrane tyrosine kinase expressed in central and peripheral nervous system and neural crest-derived cells and acts as a co-receptor of GDNF family neurotrophic factor in complex with GRFα family proteins. RET protein comprises an extracellular portion with four cadherine-like domains and a cysteine- rich region important for intermolecular interactions; a hydrophobic transmembrane domain; an...
Paper Details
Title
Development of RET Kinase Inhibitors for Targeted Cancer Therapy
Published Date
Jan 1, 2011
Journal
Volume
18
Issue
2
Pages
162 - 175
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Notes
History