Neurophysiological pharmacodynamic measures of groups and individuals extended from simple cognitive tasks to more “lifelike” activities

Extend a method to track neurophysiological pharmacodynamics during repetitive cognitive testing to a more complex “lifelike” task. Alcohol was used as an exemplar psychoactive substance. An equation, derived in an exploratory analysis to detect alcohol’s EEGs effects during repetitive cognitive testing, was validated in a Confirmatory Study on a new group whose EEGs after alcohol and placebo were recorded during working memory testing and while...