A Study of Elevated Interleukin-8 (CXCL8) Detection of Leukocyte Migration Inhibitory Activity in Patients Allergic to Beta-Lactam Antibiotics

The leukocyte migration test (LMT) is effective in identifying the causative drug in drug allergies. Both leukocyte migration activating activity (LMAA) and leukocyte migration inhibitory activity (LMIA) are involved in the development of drug allergies. However, no cytokines associated with LMIA have been identified to date. Because CXCL8 played an important role in neutrophil infiltration and activation, we performed the LMT and measured CXCL8...