Role of interleukin-6 in immune complex induced models of vascular injury.
Abstract
Previous studies have suggested that Interleukin-6 (IL-6) acts as a marker of vasculitis. To determine the role of IL-6 in vasculitis we utilized two models of immune complex induced vascular injury (dermal Arthus and acute pulmonary alveolitis) in IL-6 deficient (IL-6−/−) and IL-6 sufficient (IL-6+/+) mice. Plasma and bronchoalveolar lavage (BAL) levels of IL-6 were elevated in the injured IL-6+/+ mice with acute alveolitis and in the plasma of...
Paper Details
Title
Role of interleukin-6 in immune complex induced models of vascular injury.
Published Date
Nov 7, 2006
Journal
Volume
29
Issue
4
Pages
154 - 162
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