Challenging role of Wnt5a and its signaling pathway in cancer metastasis (Review)

Wnt5a is a noncanonical signaling member of the wingless‑related/mouse mammary tumor virus integration family, which is involved in a wide range of cellular processes, particularly in cancer development and metastasis. Accumulating evidence indicates that Wnt5a exhibits paradoxical effects in various types of cancer metastasis. Therefore, the Wnt5a signaling cascade in cancer metastasis appears to be complex and may depend on binding receptors,...