Mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2–dependent pathways are essential for CD8+ T cell–mediated airway hyperresponsiveness and inflammation

Ligation of the leukotriene B(4) (LTB(4)) receptor 1 on effector memory CD8(+) T cells by LTB(4) is important for the recruitment of CD8(+) T cells into the airways, which appears central to the induction of airway hyperresponsiveness (AHR) and allergic inflammation. Phosphorylation of extracellular signal-regulated kinase (ERK) is important in activation and cytokine production from many cell types.The roles of ERKs in effector CD8(+) T-cell...