BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens
Abstract
In order to access beta-secretase (BACE1), and enzyme strongly implicated in the cause of Alzheimer's disease, inhibitors must possess sufficient lipophilicity to traverse two lipid bilayers. Current drug candidates, which are almost totally peptide-derived, are thus inefficient because cell permeability presents a serious limiting factor. In this study, lipophilic alkylated (C(10)-C(5)) flavanones from Sophora flavescens were examined for their...
Paper Details
Title
BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens
Published Date
Jul 1, 2008
Volume
16
Issue
14
Pages
6669 - 6674
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