Airway wall structure assessed by endobronchial ultrasonography and bronchial hyperresponsiveness in patients with asthma.

Published on Oct 1, 2010in Journal of bronchology & interventional pulmonology
· DOI :10.1097/LBR.0B013E3181F9F09B
Toshiyuki Kita15
Estimated H-index: 15
(St. Marianna University School of Medicine),
Masaki Fujimura53
Estimated H-index: 53
+ 6 AuthorsShinji Nakao59
Estimated H-index: 59
BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the relationship between the wall structure assessed by using endobronchial ultrasonography (EBUS) and bronchial hyperresponsiveness in patients with asthma. METHODS: Twenty-four patients with stable asthma and 11 individuals without asthma were studied. EBUS was performed with a radial 20-MHz ultrasonic probe inserted into the intermediate bronchus undergoing flexible bronchoscopy to assess the airway wall structure. The percentage of airway wall thickness {WT%; defined as [(ideal outer diameter-ideal luminal diameter)/ideal outer diameter]×100} was determined by EBUS. We measured bronchial hyperresponsiveness to methacholine [the provocative concentration of methacholine causing a decrease of 20% or more in forced expiratory volume in 1 s (PC20)]. RESULTS: Percentage wall thickness measured by EBUS was significantly greater in patients with asthma than that in subjects without asthma (P<0.01). The evaluation of the laminar structure using EBUS indicated that the thickness of the second layer in patients with asthma was greater than that in subjects without asthma (P<0.05). PC20 was negatively correlated with the thickness of the second layer (r=0.52, P<0.01) but was not significantly correlated with other layers in patients with asthma. CONCLUSIONS: The evaluation of the bronchial mural structure using EBUS might be advantageous for assessing the relationship between airway wall remodeling and bronchial hyperresponsiveness.
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