CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis

Summary The role of CX3CR1 in regulating the function of monocytes and microglia was examined in mice in which CX3CR1 had been replaced by green fluorescent protein (GFP). Induction of experimental autoimmune uveitis (EAU) in these mice resulted in increased disease severity at day 23 postimmunization with uveitogenic peptide when compared with CX3CR1‐positive mice and increased apoptosis of neuronal cells in the inner nuclear layer. Resident...