Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability
Abstract
The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vitro and in vivo for regenerative medicine strategies. Although fibronectin (FN), a crucial ECM protein in tissue development and repair, and its RGD peptide are widely used for cell adhesion,...
Paper Details
Title
Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability
Published Date
Feb 1, 2009
Journal
Volume
30
Issue
6
Pages
1089 - 1097
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Notes
History