Orexin in sleep, addiction and more: Is the perfect insomnia drug at hand?
Abstract
Orexins A and B (hypocretins 1 and 2) and their two receptors (OX1R and OX2R) were discovered in 1998 by two different groups. Orexin A and B are derived from the differential processing of a common precursor, the prepro-orexin peptide. The neuropeptides are expressed in a few thousand cells located in the lateral hypothalamus (LH), but their projections and receptor distribution are widespread throughout the brain. Remarkably, prepro peptide...
Paper Details
Title
Orexin in sleep, addiction and more: Is the perfect insomnia drug at hand?
Published Date
Dec 1, 2013
Journal
Volume
47
Issue
6
Pages
477 - 488
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Notes
History