Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase.

Volume: 80, Issue: 4, Pages: 694 - 703
Published: Oct 1, 2011
Abstract
Toward developing antileishmanial agents with mode of action targeted to DNA topoisomerases of Leishmania donovani , we have synthesized a large number of derivatives of betulin. The compound, a natural triterpene isolated from the cork layer of Betula spp. plants exhibits several pharmacological properties. Three compounds (disuccinyl betulin, diglutaryl dihydrobetulin, and disuccinyl dihydrobetulin) inhibit growth of the parasite as well as...
Paper Details
Title
Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase.
Published Date
Oct 1, 2011
Volume
80
Issue
4
Pages
694 - 703
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