Peptide leukotrienes mediate acetaldehyde-induced bronchial hyper-responsiveness in guinea-pigs

Summary Background We previously reported that inhaled acetaldehyde, a metabolite of ethanol atid a maiti factor in alcohol‐induced asthma, causes bronchial hyper‐responsiveness (BHR) in asthmatics. However, the mechanisms are unclear. Objective The purpose of this study was to investigate a role of a peptide leukotriene (LT) in acetaldehyde‐induced BHR. Methods Effects of LT antagonists, ONO‐1078 (O.l‐l.Omg/kg) and ICI‐198, 615 (0.03–0.3...