Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model
Abstract
Loss of basal forebrain cholinergic neurons is an early and key feature of Alzheimer's disease, and magnetic resonance imaging (MRI) volumetric measurement of the basal forebrain has recently gained attention as a potential diagnostic tool for this condition. The aim of this study was to determine whether loss of basal forebrain cholinergic neurons underpins changes which can be detected through diffusion MRI using diffusion tensor imaging (DTI)...
Paper Details
Title
Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model
Published Date
Feb 1, 2013
Journal
Volume
66
Pages
133 - 141
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