A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays.

Volume: 87, Issue: 6, Pages: 521 - 525
Published: Apr 10, 2012
Abstract
It is difficult task to measure precisely the toxic effect of beta-amyloid (Aβ 1-42) peptides and also the protective effect of novel drug candidates against Aβ-peptides. The widely used MTT-assay in cell lines or primary cell cultures could be insensitive against Aβ-peptides. We describe here an easy and relevant method for testing Aβ 1-42 toxicity on acute hippocampal slices derived from rat. Brain slice viability in different conditions was...
Paper Details
Title
A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays.
Published Date
Apr 10, 2012
Volume
87
Issue
6
Pages
521 - 525
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