Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice

Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa. This study investigated the effect of spinosin on cholinergic blockade-induced memory impairment in mice. Behavioral tests were conducted using the passive avoidance, Y-maze, and Morris water maze tasks to evaluate the memory-ameliorating effect of spinosin. Spinosin (10 or 20 mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive...