ADME of Antibody–Maytansinoid Conjugates
Abstract
The concept of treating cancer with antibody-drug conjugates (ADCs) has gained momentum with the favorable activity and safety of trastuzumab emtansine (T-DM1), SAR3419, and lorvotuzumab mertansine (IMGN901). All three ADCs utilize maytansinoid cell-killing agents which target tubulin and suppress microtubule dynamics. Each ADC utilizes a different optimized chemical linker to attach the maytansinoid to the antibody. Characterizing the...
Paper Details
Title
ADME of Antibody–Maytansinoid Conjugates
Published Date
Aug 9, 2012
Journal
Volume
14
Issue
4
Pages
799 - 805
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Notes
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