Activation of STAT1 is required for interferon-alpha-mediated cell death.
Abstract
null null Interferon-alpha (IFNα)-induced cell death of tumor cells is likely mediated through several signaling pathways. We previously demonstrated that blocking the activation of phosphoinositide-3-kinase, PI3K, or mammalian target of rapamycin, mTOR, partially inhibited apoptosis induced by IFNα. Here, we postulate using pharmacological inhibition and dominant negative mutants that activation of signal transducer and activator of...
Paper Details
Title
Activation of STAT1 is required for interferon-alpha-mediated cell death.
Published Date
Jan 1, 2011
Journal
Volume
317
Issue
1
Pages
9 - 19
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Notes
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