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doi.org/10.1016/j.mrfmmm.2011.11.008

Niacin requirements for genomic stability

James B. Kirkland
22
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis2.30
Volume: 733, Issue: 1-2, Pages: 14 - 20
Published: May 1, 2012
Abstract
Through its involvement in over 400 NAD(P)-dependent reactions, niacin status has the potential to influence every area of metabolism. Niacin deficiency has been linked to genomic instability largely through impaired function of the poly ADP-ribose polymerase (PARP) family of enzymes. In various models, niacin deficiency has been found to cause impaired cell cycle arrest and apoptosis, delayed DNA excision repair, accumulation of single and...
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Paper Details
Title
Niacin requirements for genomic stability
DOI
doi.org/10.1016/j.mrfmmm.2011.11.008
Published Date
May 1, 2012
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume
733
Issue
1-2
Pages
14 - 20
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