The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and Ca V 1.2 Channels
Abstract
Calcium signals, pivotal in controlling cell function, can be generated by calcium entry channels activated by plasma membrane depolarization or depletion of internal calcium stores. We reveal a regulatory link between these two channel subtypes mediated by the ubiquitous calcium-sensing STIM proteins. STIM1 activation by store depletion or mutational modification strongly suppresses voltage-operated calcium (Ca(V)1.2) channels while activating...
Paper Details
Title
The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and Ca V 1.2 Channels
Published Date
Oct 1, 2010
Journal
Volume
330
Issue
6000
Pages
105 - 109
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