LRP8 mediates Wnt/β‐catenin signaling and controls osteoblast differentiation

The Wnt/β‐catenin signaling pathway plays a pivotal role in regulating osteoblast differentiation and bone formation. Here, we identify low‐density lipoprotein (LDL) receptor‐related protein 8 (LRP8) as a positive regulator of Wnt/β‐catenin signaling. In a small interfering RNA (siRNA) screen, LRP8 was shown to be required for Wnt/β‐catenin–induced transcriptional reporter activity. We found that ectopic expression of LRP8 increased Wnt‐induced...