Infection–induced Bystander-Apoptosis of Monocytes Is TNF-alpha-mediated
Abstract
Phagocytosis induced cell death (PICD) is crucial for controlling phagocyte effector cells, such as monocytes, at sites of infection, and essentially contributes to termination of inflammation. Here we tested the hypothesis, that during PICD bystander apoptosis of non-phagocyting monocytes occurs, that apoptosis induction is mediated via tumor necrosis factor-alpha (TNF-α and that TNF-α secretion and -signalling is causal. Monocytes were...
Paper Details
Title
Infection–induced Bystander-Apoptosis of Monocytes Is TNF-alpha-mediated
Published Date
Jan 17, 2013
Journal
Volume
8
Issue
1
Pages
e53589 - e53589
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