In situ tissue regeneration through host stem cell recruitment.

Published on Nov 15, 2013in Experimental and Molecular Medicine8.718
· DOI :10.1038/EMM.2013.118
In Kap Ko16
Estimated H-index: 16
(Wake Forest Institute for Regenerative Medicine),
Sang Jin Lee54
Estimated H-index: 54
(Wake Forest Institute for Regenerative Medicine)
+ 1 AuthorsJames J. Yoo90
Estimated H-index: 90
(Wake Forest Institute for Regenerative Medicine)
A review of strategies for mobilizing the body's stem cell reservoirs documents steady progress in accelerating the repair of damaged tissues. Foreign tissue grafts can treat disease and injury, but carry the risk of host rejection. Treatments using a patient's cultured stem cells circumvent rejection, but such procedures are complex and laborious. James Yoo and colleagues at Wake Forest School of Medicine, USA, explored a promising alternative: biodegradable implants that recruit local pools of stem cells for tissue repair. Such implants typically consist of non-toxic scaffold materials that support cell growth at the site of injury. These are accompanied by signaling factors that ‘awaken’ dormant stem cells, typically given by injection or released directly from the scaffold. Early results in muscle and bone show promise, but further research is required before in situ tissue regeneration becomes clinical reality.
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